| Club | Founded | Stadium (capacity) | National titles |
| Bella Vista | 04/10/1920 | Estadio Parque Jose Nesazzi, Montevideo (15,000) | 1990 |
| Central Espanol | 05/01/1905 | Parque Pallermo, Montevideo (6,500) | |
| Cerrito | 28/10/1929 | Estadio Charrua, Montevideo (12,000) | |
| Cerro Porteno | 01/09/1922 | Estadio Luis Troccoli, Montevideo (25,000) | |
| Danubio | 01/03/1932 | Jardines del Hipodromo, Montevideo (16,000) | 1988, 2004 |
| Defensor Sporting | 15/03/1913 | Estadio Luis Franzini, Montevideo (18,000) | 1976, 1987, 1991 |
| Deportivo Colonia | 10/10/1999 | Estadio Campomar, Juan Lacaze (8,000) | |
| Liverpool | 12/02/1915 | Estadio Belvedere, Montevideo (9,500) | |
| Miramar Misiones | 26/03/1906 | Estadio Mendez Piana, Montevideo (4,000) | |
| Nacional | 14/05/1899 | Estadio Parque Central, Montevideo (22,000) | 1902, 1903, 1912, 1915, 1916, 1917, 1919, 1920, 1922, 1923, 1924, 1933, 1934, 1939, 1940, 1941, 1942, 1943, 1946, 1947, 1950, 1952, 1956, 1957, 1963, 1966, 1969, 1970, 1971, 1972, 1977, 1980, 1983, 1992, 1998, 2000, 2001, 2002, 2005 |
| Penarol | 13/12/1913 | Estadio Centenario, Montevideo (80,000) | 1918, 1921, 1925, 1926, 1928, 1929, 1932, 1935, 1936, 1937, 1938, 1944, 1945, 1949, 1951, 1953, 1954, 1958, 1959, 1960, 1961, 1962, 1964, 1965, 1967, 1968, 1973, 1974, 1975, 1978, 1979, 1981, 1982, 1985, 1986, 1993, 1994, 1995, 1996, 1997, 1999, 2003 |
| Rampla Juniors | 07/01/1914 | Estadio Olimpico, Montevideo (9,500) | |
| Rentistas | 26/03/1933 | Complejo Rentistas, Montevideo (10,000) | |
| River Plate | 11/05/1932 | Estadio Federico Saroldi, Montevideo (12,000) | |
| Rocha FC | 01/08/1999 | Estadio Mario Sobrero, Rocha (8,000) | |
| Tacuarembo | 1998 | Estadio Raul Goyenola, Tacuarembo (12,000) | |
| Wanderers | 25/08/1902 | Alfredo Victor Viera, Montevideo (12,500) |