| 29/01/08 05/02/08 | Arsenal (ARG) Mineros de Guyana (VEN) | 2-0 2-1 (Agg. 2-3) | Mineos de Guyana (VEN) Arsenal (ARG) |
| 30/01/08 06/02/08 | Cruzeiro (BRA) Cerro Porteño (PAR) | 3-1 2-3 (Agg. 3-6) | Cerro Porteño (PAR) Cruzeiro (BRA) |
| 30/01/08 05/02/08 | Atlas (MEX) La Paz FC (BOL) | 2-0 1-0 (Agg. 1-2) | La Paz FC (BOL) Atlas (MEX) |
| 31/01/08 05/02/08 | Olmedo (ECU) CA Lanús (ARG) | 1-0 3-0 (Agg. 3-1) | CA Lanús (ARG) Olmedo (ECU) |
| 07/02/08 12/02/08 | Cienciano (PER) Montevideo Wanderers (URU) | 1-0 0-0 (Agg. 0-1) | Montevideo Wanderers(URU) Cienciano (PER) |
| 07/02/08 12/02/08 | Chicó FC (COL) Audax Italiano (CHI) | 4-3 1-0 (Agg. 4-4)* | Audax Italiano (CHI) Chicó FC (COL) |
| Team | GP | W | D | L | GF | GA | GD | Pts. | |
| 1 | Cruzeiro (BRA) | 2 | 1 | 1 | 0 | 3 | 0 | 3 | 4 |
| 2 | Caracas FC (VEN) | 1 | 1 | 0 | 0 | 2 | 0 | 2 | 3 |
| 4 | San Lorenzo (ARG) | 2 | 0 | 1 | 1 | 0 | 2 | -2 | 1 |
| 5 | Bamin Real Potosí (BOL) | 1 | 0 | 0 | 1 | 0 | 3 | -3 | 0 |
| Date | Home Team | Away Team | |
| 12/02/08 13/02/08 21/02/08 26/02/08 04/03/08 11/03/08 18/03/08 25/03/08 01/04/08 03/04/08 16/04/08 18/04/08 | Caracas FC Cruzeiro San Lorenzo Caracas FC Cruzeiro Bamin Real Potosí Caracas FC San Lorenzo Bamin Real Potosí Cruzeiro Bamin Real Potosí San Lorenzo | 2-0 3-0 0-0 | San Lorenzo Bamin Real Potosí Cruzeiro Bamin Real Potosí Caracas FC San Lorenzo Cruzeiro Bamin Real Potosí Caracas FC San Lorenzo Cruzeiro Caracas FC |
| Team | GP | W | D | L | GF | GA | GD | Pts | |
| 1 | Deportivo Cuenca (ECU) | 2 | 1 | 1 | 0 | 1 | 0 | 1 | 4 |
| 2 | CA Lanús (ARG) | 1 | 1 | 0 | 0 | 3 | 1 | 2 | 3 |
| 3 | Danubio (URU) | 2 | 0 | 1 | 1 | 1 | 3 | -2 | 1 |
| 4 | Estudiantes LP (ARG) | 1 | 0 | 0 | 1 | 0 | 1 | -1 | 0 |
| Date | Home Team | Away Team | |
| 12/02/08 14/02/08 21/02/08 26/02/06 05/03/08 13/03/08 18/03/08 20/03/08 27/03/08 02/04/08 15/04/08 15/04/08 | Deportivo Cuenca CA Lanús Deportivo Cuenca Estudiantes LP Danubio CA Lanús Estudiantes LP Deportivo Cuenca Danubio CA Lanús Danubio Estudiantes LP | 1-0 3-1 0-0 | Estudiantes LP Danubio Danubio CA Lanús Estudiantes LP Deportivo Cuenca Danubio CA Lanús Deportivo Cuenca Estudiantes LP CA Lanús Deportivo Cuenca |
| Team | GP | W | D | L | GF | GA | GD | Pts | |
| 1 | Atlas (MEX) | 1 | 1 | 0 | 0 | 3 | 0 | 3 | 3 |
| 2 | Boca Juniors (ARG) | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 |
| 3 | UA Maracaibo (VEN) | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 |
| 4 | Colo Colo (CHI) | 1 | 0 | 0 | 1 | 0 | 3 | -3 | 0 |
| Date | Home Team | Away Team | |
| 20/02/08 21/02/08 28/02/08 06/03/08 12/03/08 20/03/08 25/03/08 27/03/08 09/04/08 10/04/08 22/04/08 22/04/08 | UA Maracaibo Atlas UA Maracaibo Boca Juniors Atlas Colo Colo UA Maracaibo Boca Juniors Atlas Colo Colo Colo Colo Boca Juniors | 1-1 3-0 | Boca Juniors Colo Colo Colo Colo Atlas UA Maracaibo Boca Juniors Atlas Colo Colo Boca Juniors UA Maracaibo Atlas UA Maracaibo |
| Team | GP | W | D | L | GF | GA | GD | Pts. | |
| 1 | Cienciano (PER) | 1 | 1 | 0 | 0 | 2 | 1 | 1 | 3 |
| 2 | Nacional (URU) | 2 | 1 | 0 | 1 | 2 | 2 | 0 | 3 |
| 3 | Flamengo (BRA) | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
| 4 | Coronel Bolognesia (PER) | 2 | 0 | 1 | 1 | 0 | 1 | -1 | 1 |
| Date | Home Team | Away Team | |
| 13/02/08 14/02/08 19/02/08 27/02/08 06/03/08 11/03/08 19/03/08 25/03/08 03/04/08 09/04/08 23/04/08 23/04/08 | Coronel Bolognesi Cienciano Coronel Bolognesi Flamengo Nacional Cienciano Flamengo Coronel Bolognesi Nacional Cienciano Flamengo Nacional | 0-0 2-1 0-1 | Flamengo Nacional Nacional Cienciano Flamengo Coronel Bolognesi Nacional Cienciano Coronel Bolognesi Flamengo Coronel Bolognesi Cienciano |
| Team | GP | W | D | L | GF | GA | GD | Pts | |
| 1 | San Martín (PER) | 1 | 1 | 0 | 0 | 2 | 0 | 2 | 3 |
| 2 | CF América (MEX) | 1 | 1 | 0 | 0 | 2 | 1 | 1 | 3 |
| 3 | Universidad Católica (CHI) | 1 | 0 | 0 | 1 | 1 | 2 | -1 | 0 |
| 4 | River Plate (ARG) | 1 | 0 | 0 | 1 | 0 | 2 | -2 | 0 |
| Date | Home Team | Away Team | |
| 13/02/08 20/02/08 26/02/08 | San Martín CF América San Martín | 2-0 2-1 | River Plate Universidad Católica Universidad Católica |